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KMID : 0351619630040010001
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Kyungpook Medical Journal
1963 Volume.4 No. 1 p.1 ~ p.31
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EXPERIMENTAL STUDIES ON UROLITHIASES
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Abstract
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Author performed animal experimentation to find out the etiologic factors of urolithiasis.
Author used white rats (200 gm, body weight) for this expeirment. A suprapubicb cystot omy was performed on each rat and a piece of zinc plate (weight 50mg). was inserted within the bladder as a foreigh body. Rats were devided into two groups, control and experimental.
Within the experimental group appied various factors over a period of 2 to 3 months till found foreign body cadculi in the bladder.
On comparing the result of stone formation by foreign bodies in the bladder, found the following results:
1. Foreign body versus stone formation (zinc and lead):
Zinc foreign bodies formed larger bladder stone than lead foreign bodies.
2. Sex versus stone formation:
Male rat formed foreigh bodies 11 times larger than those of the female group.
3. Diet Versus stone formation:
a. Diet No. I group (spinach oleracea. 5-10gm daily). This diet tended to accelerate slightly the formation of bladder stones.
b. Diet No. 2 group (grass 5-10gm daily). No apparent influence on formation of bladder stones.
4. Vitamin C versus stone formation:
The experimental group received a total injection of 45-50mg of vitamin C over a period of 62 days
Stones in this group aged 50mg.. however in the control group the average weight was 55.83mg.
Vitamin C therefore would seem to have little influence on stone formation.
5. Insulin versus stone formation:
The experimental group which received a total of 21 to 27.5 units of insulin over a period of 62 days showed a 35% increase over a period of 62 days showed a 35% increase over the average stone weight of the control group.
6. Estradiol Benzoate versus stone formation: An experimental group of male rats, after injection (over a 75 day period) of a total 1.2 to 2.35gm of estradiol benzoate, showed 70mg average stone weight, compared to 247mg weight for the control group, thus estradiol benzoate inhibits stone formation.
7. Testosterone propionate versus stone formation: An experimental group of female rats, after injection (over a 75 day period) of a total of 1.25 to 2.35gm of testosterone propionate showed 98.
75mg average stone weight as compared to 69.0mg stone weight for the control group. Thus, testosterone propionate accelerates stone formation.
8. Stress versus stone formation.
a. Cortisone
An experimental group of male rats, after injection (over 62 day period) of 6.3 to 8.25mg total of cortisone acetate, showed 140mg average stone weight as compared as 55,83mg for the control group. Thus cortisone accelerates stone formation.
b.Cold;
An experimental group of male rats refrigerated 60 minutes each day at 37℉, for 54 out of 62 days, showed 66,83mg average stone weight as compared with 55.83mg for the control group.
Thus, short exposures to moderate cold have little effection stone formation
c. Ether anesthesia;
Anesthesia, using ether-drip technique, was carried out on 46 of 64 days on a male rat experimental group. This group showed 140. 83mg average stone weight as compared to 67.5mg for the control group.
9. Hyaluronidase(wydase) versus stone formation in male rats;
After injection of a total of 330 to 345 TRU of hyluronidase over a 78 day period, the experimental group showed 60.55mg stone weight as compared to 431.43mg for the control group.
10. Hyaluronidase(wydase) versus stone formation in female rats:
Experimental group: 59.38 avetage stone weight, 705 TRU over 75 days. Control group: 69mg average stone weight. Thus hyaluronidase(wydase greatly inhibits stone formation.
11. Climate versus stone formation:
Stone formation was more accelerated in winter than in summer. Server cold appears to be a stress ennancing stone formation.
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